Role Summary Lead end-to-end architecture and delivery governance for a regulated AWS platform supporting CDAP (pharmacometrics) and BEE (biostats). Own multi-environment architecture (DEV/TEST/PROD/DR) using Terraform modularization and GitOps practices. Define platform blueprint for compute, storage, networking, identity, CI/CD, observability, DR, and operational readiness.
Key ResponsibilitiesDefine target AWS architecture for VPC design with department isolation (subnets, NACLs, security groups). Architect Amazon EKS with namespace isolation (cdap/sas/gitlab) and Helm-based deployments. Architect AWS PCS (Slurm HPC) for NONMEM workloads including scaling and integration patterns. Architect storage layers using FSx NetApp ONTAP (NFS/SMB, multi-AZ) and FSx Lustre scratch for HPC. Define end-user access architecture using AWS WorkSpaces (Windows desktops) and integration touchpoints. Define data services architecture using RDS PostgreSQL and ElastiCache Redis for platform components. Design Identity & Access integration: Okta SSO + Duo MFA, AWS Managed AD, and RBAC/group strategy. Establish Infrastructure-as-Code standards: Terraform module strategy, remote state, environment variable files, and governance. Define GitOps standards: all Kubernetes manifests/Helm values in Git, CI/CD-driven promotion across environments. Define GitLab platform and pipeline strategy (runners, approvals, artifact management, reusable templates). Drive security-by-design: least privilege IAM, logging, encryption, secrets management patterns. Ensure regulated operations readiness: change control, audit readiness, validation documentation alignment (GxP/21 CFR Part 11). Define operational model: monitoring/alerting, patching cadence, backup/restore, DR runbooks, and service reporting. Create architecture deliverables: HLD/LLD, standards, reference patterns, runbooks, and handover package. Know R&D and FDA process - what we are building is tool for R&D team (to run simulation/analysis) who face FDA Audit, understanding of business and work closely with the business Work with stakeholders (client, engineering, ops) to manage risks, dependencies, and design decisions.
Must-Have SkillsExpert level AWS architecture experience: networking, compute, storage, IAM/security, multi-AZ design. Expert level Terraform experience: module design, remote state (S3 + locking), multi-environment patterns. GitLab CI/CD pipelines: design, governance, reusable templates, runner strategy. Kubernetes/EKS architecture with Helm and GitOps workflows. Strong Experience integrating /connecting On-premises Active Directory to AWS. Experience with AWS HPC workloads. Strong experience operating platforms in regulated / compliance-driven environments. Strong documentation and architecture governance skills.
Good-to-Have SkillsHave Healthcare/Pharma domain experience, with knowledge on FDA processes Experience working with business teams and R&D team with good understanding of business processes Experience with AWS PCS / Slurm. Experience with FSx NetApp ONTAP and FSx Lustre performance patterns. Experience with AWS WorkSpaces at scale. Experience designing/operating self-hosted GitLab in highly available setups. Experience with OpenKyber integration. Experience with Pharma domain an added advantage. Education / Certifications Bachelor's degree in Computer Science / IT or equivalent. Preferred AWS Solutions Architect Associate/Professional Certification.
For applications and inquiries, contact: hirings@openkyber.com
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